PEGylation of lipophilic SN38 prodrug with DSPE-mPEG(2000) versus cremophor EL: comparative study for intravenous chemotherapy

The lipophilic prodrug of hydrophobic drugs with well-designed molecular structures can form stable pure prodrug nanoparticles (NPs), but rapid NPs aggregation in plasma greatly restricted their direct use for intravenous chemotherapy. To address this, DSPE-mPEG(2000) and Cremophor EL are two of the...

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Bibliografiske detaljer
Udgivet i:Drug Deliv
Main Authors: Zeng, Jun, Li, Chen, Duan, Xing, Liu, Fuyue, Li, Anqin, Luo, Chunhan, Jia, Li, Gan, Yifang, Yan, Lu, Zheng, Yaxin
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442117/
https://ncbi.nlm.nih.gov/pubmed/30909751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2019.1587045
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