Doxorubicin Delivered by A Redox-responsive Dasatinib-containing Polymeric Prodrug Carrier for Combination Therapy

Two novel prodrug polymers POEG-b-PSSDas (redox-sensitive) and POEG-b-PCCDas (redox-insensitive), which consist of poly(oligo(ethylene glycol) methacrylate) (POEG) hydrophilic blocks and dasatinib (DAS, an oncogenic tyrosine kinases inhibitor) conjugated hydrophobic blocks, were designed as dual-fun...

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Veröffentlicht in:J Control Release
Hauptverfasser: Sun, Jingjing, Liu, Yanhua, Chen, Yichao, Zhao, Wenchen, Zhai, Qianyu, Rathod, Sanjay, Huang, Yixian, Tang, Suoqin, Kwon, Yong Tae, Fernandez, Christian, Venkataramanan, Raman, Li, Song
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5525542/
https://ncbi.nlm.nih.gov/pubmed/28501705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2017.05.006
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