Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapy

A simple PEGylated peptidic nanocarrier, PEG(5000)-lysyl-(α-Fmoc-ε-Cbz-lysine)(2) (PLFCL)(,) was developed for effective co-delivery of doxorubicin (DOX) and dasatinib (DAS) for combination chemotherapy. Significant synergy of DOX and DAS in inhibition of cancer cell proliferation was demonstrated i...

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Bibliografiske detaljer
Udgivet i:Biomaterials
Main Authors: Zhang, Peng, Li, Jiang, Ghazwani, Mohammed, Zhao, Wenchen, Huang, Yixian, Zhang, Xiaolan, Venkataramanan, Raman, Li, Song
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4550547/
https://ncbi.nlm.nih.gov/pubmed/26210177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2015.07.027
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