Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement

Testing of an expanded, 800-compound set of analogues of the earlier described Strecker-type α-aminonitriles (selected from publicly available Enamine Ltd. Screening Collection) in thermal shift assay against bovine carbonic anhydrase (bCA) led to further validation of this new class of inhibitors a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Krasavin, Mikhail, Kalinin, Stanislav, Zozulya, Sergey, Griniukova, Anastasia, Borysko, Petro, Angeli, Andrea, Supuran, Claudiu T.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6882446/
https://ncbi.nlm.nih.gov/pubmed/31752557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1693556
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados