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An in silico analysis of robust but fragile gene regulation links enhancer length to robustness

Organisms must ensure that expression of genes is directed to the appropriate tissues at the correct times, while simultaneously ensuring that these gene regulatory systems are robust to perturbation. This idea is captured by a mathematical concept called r-robustness, which says that a system is ro...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: Barr, Kenneth, Reinitz, John, Radulescu, Ovidiu
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881076/
https://ncbi.nlm.nih.gov/pubmed/31730659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007497
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