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Synthetic enhancer design by in silico compensatory evolution reveals flexibility and constraint in cis-regulation

BACKGROUND: Models that incorporate specific chemical mechanisms have been successful in describing the activity of Drosophila developmental enhancers as a function of underlying transcription factor binding motifs. Despite this, the minimum set of mechanisms required to reconstruct an enhancer from...

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Bibliografski detalji
Izdano u:BMC Syst Biol
Glavni autori: Barr, Kenneth A., Martinez, Carlos, Moran, Jennifer R., Kim, Ah-Ram, Ramos, Alexandre F., Reinitz, John
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5708098/
https://ncbi.nlm.nih.gov/pubmed/29187214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-017-0485-2
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