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Small Molecule Interactome Mapping by Photo-Affinity Labeling (SIM-PAL) to Identify Binding Sites of Small Molecules on a Proteome-Wide Scale
Identification and characterization of small molecule–protein interactions is critical to understanding the mechanism of action of bioactive small molecules. Photo-affinity labeling (PAL) enables the capture of non-covalent interactions for enrichment and unbiased analysis by mass spectrometry (MS)....
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| Publié dans: | Curr Protoc Chem Biol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6880798/ https://ncbi.nlm.nih.gov/pubmed/31763793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpch.75 |
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