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Proteome-wide small molecule and metabolite interaction mapping
Thermal stabilization of proteins upon ligand binding provides an efficient means to assess binding of small molecules to proteins. We show here that in combination with quantitative mass spectrometry the approach allows for the systematic survey of protein engagement by cellular metabolites and dru...
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| Publicado no: | Nat Methods |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629415/ https://ncbi.nlm.nih.gov/pubmed/26389571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3590 |
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