Histone deacetylase inhibition promotes intratumoral CD8(+) T-cell responses, sensitizing murine breast tumors to anti-PD1

Histone deacetylase (HDAC) inhibitors impair tumor cell proliferation and alter gene expression. However, the impact of these changes on anti-tumor immunity is poorly understood. Here, we showed that the class I HDAC inhibitor, entinostat (ENT), promoted the expression of immune-modulatory molecules...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: McCaw, Tyler R., Li, Mei, Starenki, Dmytro, Liu, Mingyong, Cooper, Sara J., Arend, Rebecca C., Forero, Andres, Buchsbaum, Donald J., Randall, Troy D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879872/
https://ncbi.nlm.nih.gov/pubmed/31720815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-019-02430-9
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