Germ-line genetic variation in the immunoglobulin heavy chain creates stroke susceptibility in the spontaneously hypertensive rat

The risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring genetic variation. In the present study we show the involvement of SHR genetic variation that affects antibody formation and function in the pathogenesis of stroke. We h...

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Veröffentlicht in:Physiol Genomics
Hauptverfasser: Dhande, Isha S., Kneedler, Sterling C., Joshi, Aniket S., Zhu, Yaming, Hicks, M. John, Wenderfer, Scott E., Braun, Michael C., Doris, Peter A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879812/
https://ncbi.nlm.nih.gov/pubmed/31608789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00054.2019
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