Safety, Tolerability, and Pharmacokinetics of Oral Nafithromycin (WCK 4873) after Single or Multiple Doses and Effects of Food on Single-Dose Bioavailability in Healthy Adult Subjects

Nafithromycin (WCK 4873), a novel lactone-ketolide, was administered to healthy adult subjects in 2 randomized, double-blind, placebo-controlled, phase 1 studies. In the first-in-human study, single ascending oral doses of nafithromycin (100 to 1,200 mg) were administered to subjects under fasted or...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Iwanowski, Piotr, Bhatia, Ashima, Gupta, Mugdha, Patel, Anasuya, Chavan, Rajesh, Yeole, Ravindra, Friedland, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6879255/
https://ncbi.nlm.nih.gov/pubmed/31591119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01253-19
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