Plasma and Intrapulmonary Concentrations of Cefepime and Zidebactam following Intravenous Administration of WCK 5222 to Healthy Adult Subjects

WCK 5222 is a combination of cefepime and the novel β-lactam enhancer zidebactam being developed for the treatment of serious Gram-negative bacterial infections. The objective of this study was to compare plasma (total), epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of c...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Rodvold, Keith A., Gotfried, Mark H., Chugh, Rakesh, Gupta, Mugdha, Patel, Anasuya, Chavan, Rajesh, Yeole, Ravindra, Friedland, H. David, Bhatia, Ashima
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6105785/
https://ncbi.nlm.nih.gov/pubmed/29784852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00682-18
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