Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects

Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Rodvold, Keith A., Gotfried, Mark H., Chugh, Rakesh, Gupta, Mugdha, Yeole, Ravindra, Patel, Anasuya, Bhatia, Ashima
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826115/
https://ncbi.nlm.nih.gov/pubmed/29263070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02297-17
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