Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects

Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Rodvold, Keith A., Gotfried, Mark H., Chugh, Rakesh, Gupta, Mugdha, Yeole, Ravindra, Patel, Anasuya, Bhatia, Ashima
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826115/
https://ncbi.nlm.nih.gov/pubmed/29263070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02297-17
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