Intrapulmonary Pharmacokinetics of Levonadifloxacin following Oral Administration of Alalevonadifloxacin to Healthy Adult Subjects

Alalevonadifloxacin (WCK 2349) is a novel l-alanine ester prodrug of levonadifloxacin that is being developed as an oral fluoroquinolone antibiotic. The primary objective of this study was to determine and compare plasma, epithelial lining fluid (ELF), and alveolar macrophage (AM) concentrations of...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Rodvold, Keith A., Gotfried, Mark H., Chugh, Rakesh, Gupta, Mugdha, Yeole, Ravindra, Patel, Anasuya, Bhatia, Ashima
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826115/
https://ncbi.nlm.nih.gov/pubmed/29263070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02297-17
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