Single-Center Investigation of the Pharmacokinetics of WCK 4282 (Cefepime-Tazobactam Combination) in Renal Impairment

WCK 4282 is a combination product of cefepime (FEP) and tazobactam (TAZ) in a 1:1 ratio currently under development for the treatment of multidrug-resistant Gram-negative bacterial infections. We investigated the effect of renal impairment on the pharmacokinetics (PK) and safety of WCK 4282 in 48 su...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Preston, Richard A., Mamikonyan, Grigor, Mastim, Mushtaque, Garg, Dyal, Kemper, Christopher J., Xu, Allan, Yeole, Ravindra, Chavan, Rajesh, Friedland, H. David, Bhatia, Ashima
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2019
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761517/
https://ncbi.nlm.nih.gov/pubmed/31332068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00873-19
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