Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age

Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between the sexes. Skewed XCI toward one parental X has been observed in several complex human traits, but the extent to which genetics and environment influence skewed XCI is largely unexplored. To address...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Zito, Antonino, Davies, Matthew N., Tsai, Pei-Chien, Roberts, Susanna, Andres-Ejarque, Rosa, Nardone, Stefano, Bell, Jordana T., Wong, Chloe C. Y., Small, Kerrin S.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877649/
https://ncbi.nlm.nih.gov/pubmed/31767861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13340-w
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