Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort

Changes in the mean and variance of gene expression with age have consequences for healthy aging and disease development. Age-dependent changes in phenotypic variance have been associated with a decline in regulatory functions leading to increase in disease risk. Here, we investigate age-related mea...

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Publicado en:Hum Mol Genet
Autores principales: Viñuela, Ana, Brown, Andrew A, Buil, Alfonso, Tsai, Pei-Chien, Davies, Matthew N, Bell, Jordana T, Dermitzakis, Emmanouil T, Spector, Timothy D, Small, Kerrin S
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2018
Materias:
Association Studies Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886097/
https://ncbi.nlm.nih.gov/pubmed/29228364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx424
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