Genetic interactions affecting human gene expression identified by variance association mapping

Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci. Interactions give rise to genotype dependent variance, and therefore the identification of variance qu...

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Detalhes bibliográficos
Main Authors: Brown, Andrew Anand, Buil, Alfonso, Viñuela, Ana, Lappalainen, Tuuli, Zheng, Hou-Feng, Richards, J Brent, Small, Kerrin S, Spector, Timothy D, Dermitzakis, Emmanouil T, Durbin, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017648/
https://ncbi.nlm.nih.gov/pubmed/24771767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01381
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