Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity

CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched F-actin is generated by the nucleation factor actin-related protein 2/3 (Arp2...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Randzavola, Lyra O., Strege, Katharina, Juzans, Marie, Asano, Yukako, Stinchcombe, Jane C., Gawden-Bone, Christian M., Seaman, Matthew N.J., Kuijpers, Taco W., Griffiths, Gillian M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877333/
https://ncbi.nlm.nih.gov/pubmed/31710310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129388
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