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Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity
CD8 cytotoxic T lymphocytes (CTLs) rely on rapid reorganization of the branched F-actin network to drive the polarized secretion of lytic granules, initiating target cell death during the adaptive immune response. Branched F-actin is generated by the nucleation factor actin-related protein 2/3 (Arp2...
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| 出版年: | J Clin Invest |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Clinical Investigation
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6877333/ https://ncbi.nlm.nih.gov/pubmed/31710310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI129388 |
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