Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm

Delayed ischemic neurological deficit (DIND) is a major driver of adverse outcomes in patients with aneurysmal subarachnoid hemorrhage (aSAH), defining an unmet need for therapeutic development. Cell-free hemoglobin that is released from erythrocytes into the cerebrospinal fluid (CSF) is suggested t...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Hugelshofer, Michael, Buzzi, Raphael M., Schaer, Christian A., Richter, Henning, Akeret, Kevin, Anagnostakou, Vania, Mahmoudi, Leila, Vaccani, Raphael, Vallelian, Florence, Deuel, Jeremy W., Kronen, Peter W., Kulcsar, Zsolt, Regli, Luca, Baek, Jin Hyen, Pires, Ivan S., Palmer, Andre F., Dennler, Matthias, Humar, Rok, Buehler, Paul W., Kircher, Patrick R., Keller, Emanuela, Schaer, Dominik J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877320/
https://ncbi.nlm.nih.gov/pubmed/31454333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130630
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