Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis

Rationale: Hemolysis occurs not only in conditions such as sickle cell disease and malaria but also during transfusion of stored blood, extracorporeal circulation, and sepsis. Cell-free Hb depletes nitric oxide (NO) in the vasculature, causing vasoconstriction and eventually cardiovascular complicat...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Schaer, Christian A., Deuel, Jeremy W., Schildknecht, Daniela, Mahmoudi, Leila, Garcia-Rubio, Ines, Owczarek, Catherine, Schauer, Stefan, Kissner, Reinhard, Banerjee, Uddyalok, Palmer, Andre F., Spahn, Donat R., Irwin, David C., Vallelian, Florence, Buehler, Paul W., Schaer, Dominik J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872667/
https://ncbi.nlm.nih.gov/pubmed/26694989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201510-2058OC
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