Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

The parathyroid hormone 1 receptor (PTH1R) mediates the biologic actions of parathyroid hormone (PTH) and parathyroid hormone–related protein (PTHrP). Here, we showed that salt-inducible kinases (SIKs) are key kinases that control the skeletal actions downstream of PTH1R and that this GPCR, when act...

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Vydáno v:J Clin Invest
Hlavní autoři: Nishimori, Shigeki, O’Meara, Maureen J., Castro, Christian D., Noda, Hiroshi, Cetinbas, Murat, da Silva Martins, Janaina, Ayturk, Ugur, Brooks, Daniel J., Bruce, Michael, Nagata, Mizuki, Ono, Wanida, Janton, Christopher J., Bouxsein, Mary L., Foretz, Marc, Berdeaux, Rebecca, Sadreyev, Ruslan I., Gardella, Thomas J., Jüppner, Harald, Kronenberg, Henry M., Wein, Marc N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6877304/
https://ncbi.nlm.nih.gov/pubmed/31430259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130126
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