ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex

DNA replication stress-mediated activation of the ATR kinase pathway is important for maintaining genomic stability. In this study, we identified a zinc finger protein, ZFP161 that functions as a replication stress response factor in ATR activation. Mechanistically, ZFP161 acts as a scaffolding prot...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Kim, Wootae, Zhao, Fei, Wu, Rentian, Qin, Sisi, Nowsheen, Somaira, Huang, Jinzhou, Zhou, Qin, Chen, Yuping, Deng, Min, Guo, Guijie, Luo, Kuntian, Lou, Zhenkun, Yuan, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876566/
https://ncbi.nlm.nih.gov/pubmed/31757956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13321-z
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