Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

The early stages of age-related macular degeneration (AMD) are characterized by the accumulation of basal laminar deposits (BLamDs). The mechanism for BLamDs accumulating between the retinal pigment epithelium (RPE) and its basal lamina remains elusive. Here we examined the role in AMD of lysosome-a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Notomi, Shoji, Ishihara, Kenji, Efstathiou, Nikolaos E., Lee, Jong-Jer, Hisatomi, Toshio, Tachibana, Takashi, Konstantinou, Eleni K., Ueta, Takashi, Murakami, Yusuke, Maidana, Daniel E., Ikeda, Yasuhiro, Kume, Shinji, Terasaki, Hiroto, Sonoda, Shozo, Blanz, Judith, Young, Lucy, Sakamoto, Taiji, Sonoda, Koh-Hei, Saftig, Paul, Ishibashi, Tatsuro, Miller, Joan W., Kroemer, Guido, Vavvas, Demetrios G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876195/
https://ncbi.nlm.nih.gov/pubmed/31699817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906643116
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