Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina

The early stages of age-related macular degeneration (AMD) are characterized by the accumulation of basal laminar deposits (BLamDs). The mechanism for BLamDs accumulating between the retinal pigment epithelium (RPE) and its basal lamina remains elusive. Here we examined the role in AMD of lysosome-a...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Notomi, Shoji, Ishihara, Kenji, Efstathiou, Nikolaos E., Lee, Jong-Jer, Hisatomi, Toshio, Tachibana, Takashi, Konstantinou, Eleni K., Ueta, Takashi, Murakami, Yusuke, Maidana, Daniel E., Ikeda, Yasuhiro, Kume, Shinji, Terasaki, Hiroto, Sonoda, Shozo, Blanz, Judith, Young, Lucy, Sakamoto, Taiji, Sonoda, Koh-Hei, Saftig, Paul, Ishibashi, Tatsuro, Miller, Joan W., Kroemer, Guido, Vavvas, Demetrios G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6876195/
https://ncbi.nlm.nih.gov/pubmed/31699817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1906643116
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