Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss o...

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Publicado en:eLife
Autores principales: Bhagat, Tushar D, Von Ahrens, Dagny, Dawlaty, Meelad, Zou, Yiyu, Baddour, Joelle, Achreja, Abhinav, Zhao, Hongyun, Yang, Lifeng, Patel, Brijesh, Kwak, Changsoo, Choudhary, Gaurav S, Gordon-Mitchell, Shanisha, Aluri, Srinivas, Bhattacharyya, Sanchari, Sahu, Srabani, Bhagat, Prafulla, Yu, Yiting, Bartenstein, Matthias, Giricz, Orsi, Suzuki, Masako, Sohal, Davendra, Gupta, Sonal, Guerrero, Paola A, Batra, Surinder, Goggins, Michael, Steidl, Ulrich, Greally, John, Agarwal, Beamon, Pradhan, Kith, Banerjee, Debabrata, Nagrath, Deepak, Maitra, Anirban, Verma, Amit
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874475/
https://ncbi.nlm.nih.gov/pubmed/31663852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50663
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