Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Although clear cell renal cell carcinoma (ccRCC) has been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine (5hmC), the prognostic impact and therapeutic targeting of this epigenetic aberrancy has not been fully explored. Analysis of 576 primary ccRCC sa...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Shenoy, Niraj, Bhagat, Tushar D., Cheville, John, Lohse, Christine, Bhattacharyya, Sanchari, Tischer, Alexander, Machha, Venkata, Gordon-Mitchell, Shanisha, Choudhary, Gaurav, Wong, Li-Fan, Gross, LouAnn, Ressigue, Emily, Leibovich, Bradley, Boorjian, Stephen A., Steidl, Ulrich, Wu, Xiaosheng, Pradhan, Kith, Gartrell, Benjamin, Agarwal, Beamon, Pagliaro, Lance, Suzuki, Masako, Greally, John M., Rakheja, Dinesh, Thompson, R. Houston, Susztak, Katalin, Witzig, Thomas, Zou, Yiyu, Verma, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436862/
https://ncbi.nlm.nih.gov/pubmed/30702441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98747
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