Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Although clear cell renal cell carcinoma (ccRCC) has been shown to result in widespread aberrant cytosine methylation and loss of 5-hydroxymethylcytosine (5hmC), the prognostic impact and therapeutic targeting of this epigenetic aberrancy has not been fully explored. Analysis of 576 primary ccRCC sa...

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Publicat a:J Clin Invest
Autors principals: Shenoy, Niraj, Bhagat, Tushar D., Cheville, John, Lohse, Christine, Bhattacharyya, Sanchari, Tischer, Alexander, Machha, Venkata, Gordon-Mitchell, Shanisha, Choudhary, Gaurav, Wong, Li-Fan, Gross, LouAnn, Ressigue, Emily, Leibovich, Bradley, Boorjian, Stephen A., Steidl, Ulrich, Wu, Xiaosheng, Pradhan, Kith, Gartrell, Benjamin, Agarwal, Beamon, Pagliaro, Lance, Suzuki, Masako, Greally, John M., Rakheja, Dinesh, Thompson, R. Houston, Susztak, Katalin, Witzig, Thomas, Zou, Yiyu, Verma, Amit
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436862/
https://ncbi.nlm.nih.gov/pubmed/30702441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98747
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