Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma, the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are not well elucidated. An epigenomic analysis of patient-derived and de-novo generated CAFs demonstrated widespread loss o...

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Vydáno v:eLife
Hlavní autoři: Bhagat, Tushar D, Von Ahrens, Dagny, Dawlaty, Meelad, Zou, Yiyu, Baddour, Joelle, Achreja, Abhinav, Zhao, Hongyun, Yang, Lifeng, Patel, Brijesh, Kwak, Changsoo, Choudhary, Gaurav S, Gordon-Mitchell, Shanisha, Aluri, Srinivas, Bhattacharyya, Sanchari, Sahu, Srabani, Bhagat, Prafulla, Yu, Yiting, Bartenstein, Matthias, Giricz, Orsi, Suzuki, Masako, Sohal, Davendra, Gupta, Sonal, Guerrero, Paola A, Batra, Surinder, Goggins, Michael, Steidl, Ulrich, Greally, John, Agarwal, Beamon, Pradhan, Kith, Banerjee, Debabrata, Nagrath, Deepak, Maitra, Anirban, Verma, Amit
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874475/
https://ncbi.nlm.nih.gov/pubmed/31663852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50663
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