Structure-activity relationship of flavin analogs that target the FMN riboswitch

The flavin mononucleotide (FMN) riboswitch is an emerging target for the development of novel RNA-targeting antibiotics. We previously discovered an FMN derivative —5FDQD— that protects mice against diarrhea-causing Clostridium difficile bacteria. Here, we present the structure-based drug design str...

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Pubblicato in:ACS Chem Biol
Autori principali: Vicens, Quentin, Mondragón, Estefanía, Reyes, Francis E., Coish, Philip, Aristoff, Paul, Berman, Judd, Kaur, Harpreet, Kells, Kevin W., Wickens, Phil, Wilson, Jeffery, Gadwood, Robert C., Schostarez, Heinrich J., Suto, Robert K., Blount, Kenneth F., Batey, Robert T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874366/
https://ncbi.nlm.nih.gov/pubmed/30107111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00533
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