Structure-activity relationship of flavin analogs that target the FMN riboswitch

The flavin mononucleotide (FMN) riboswitch is an emerging target for the development of novel RNA-targeting antibiotics. We previously discovered an FMN derivative —5FDQD— that protects mice against diarrhea-causing Clostridium difficile bacteria. Here, we present the structure-based drug design str...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Vicens, Quentin, Mondragón, Estefanía, Reyes, Francis E., Coish, Philip, Aristoff, Paul, Berman, Judd, Kaur, Harpreet, Kells, Kevin W., Wickens, Phil, Wilson, Jeffery, Gadwood, Robert C., Schostarez, Heinrich J., Suto, Robert K., Blount, Kenneth F., Batey, Robert T.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6874366/
https://ncbi.nlm.nih.gov/pubmed/30107111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00533
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