Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

Novel mechanisms of action and new chemical scaffolds are needed to rejuvenate antibacterial drug discovery, and riboswitch regulators of bacterial gene expression are a promising class of targets for the discovery of new leads. Herein, we report the characterization of 5-(3-(4-fluorophenyl)butyl)-7...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Blount, Kenneth F., Megyola, Cynthia, Plummer, Mark, Osterman, David, O'Connell, Tim, Aristoff, Paul, Quinn, Cheryl, Chrusciel, R. Alan, Poel, Toni J., Schostarez, Heinrich J., Stewart, Catherine A., Walker, Daniel P., Wuts, Peter G. M., Breaker, Ronald R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538501/
https://ncbi.nlm.nih.gov/pubmed/26169403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01282-15
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