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EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications
EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along with other PRC2 components mediates gene expression suppression via the methylation of Histone H3 at lysine 27. Recent studies have revealed a dichotomous role of EZH2 in physiology and in the pathogenesis of canc...
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| Опубликовано в: : | J Hematol Oncol |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6868783/ https://ncbi.nlm.nih.gov/pubmed/31752930 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0814-6 |
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