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HIFI-α activation underlies a functional switch in the paradoxical role of Ezh2/PRC2 in breast cancer

Despite the established oncogenic function of Polycomb repressive complex 2 (PRC2) in human cancers, its role as a tumor suppressor is also evident; however, the mechanism underlying the regulation of the paradoxical functions of PRC2 in tumorigenesis is poorly understood. Here we show that hypoxia-...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Mahara, Sylvia, Lee, Puay Leng, Feng, Min, Tergaonkar, Vinay, Chng, Wee Joo, Yu, Qiang
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932959/
https://ncbi.nlm.nih.gov/pubmed/27303043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602079113
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