Atomistic insight into the kinetic pathways for Watson–Crick to Hoogsteen transitions in DNA

DNA predominantly contains Watson–Crick (WC) base pairs, but a non-negligible fraction of base pairs are in the Hoogsteen (HG) hydrogen bonding motif at any time. In HG, the purine is rotated ∼180° relative to the WC motif. The transitions between WC and HG may play a role in recognition and replica...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Vreede, Jocelyne, Pérez de Alba Ortíz, Alberto, Bolhuis, Peter G, Swenson, David W H
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Computational Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868366/
https://ncbi.nlm.nih.gov/pubmed/31665440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz837
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