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Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury
mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated through concurrent mutations in their GTPase-activ...
Zapisane w:
| Wydane w: | Cell Discov |
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| Główni autorzy: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Publishing Group UK
2019
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6868011/ https://ncbi.nlm.nih.gov/pubmed/31754457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-019-0131-9 |
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