Concurrent activation of growth factor and nutrient arms of mTORC1 induces oxidative liver injury

mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated through concurrent mutations in their GTPase-activ...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Cho, Chun-Seok, Kowalsky, Allison H., Namkoong, Sim, Park, Sung-Rye, Wu, Shuangcheng, Kim, Boyoung, James, Amanda, Gu, Bondong, Semple, Ian A., Tohamy, Mohamed A., Solanki, Sumeet, Cho, Uhn-Soo, Greenson, Joel K., Shah, Yatrik M., Kim, Myungjin, Lee, Jun Hee
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6868011/
https://ncbi.nlm.nih.gov/pubmed/31754457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41421-019-0131-9
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