NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/protein...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Pharmacol
Autori principali: Bellozi, Paula Maria Quaglio, Gomes, Giovanni Freitas, de Oliveira, Leonardo Rossi, Olmo, Isabella Guimarães, Vieira, Érica Leandro Marciano, Ribeiro, Fabíola Mara, Fiebich, Bernd L., de Oliveira, Antônio Carlos Pinheiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2019
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864823/
https://ncbi.nlm.nih.gov/pubmed/31798451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.01345
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