Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking

A new class of triazinoindole-bearing thiosemicarbazides (1–25) was synthesized and evaluated for α-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC(50) values ranging from 1.30 ± 0.01 to 35.80 ± 0.80 μM when compared to standard acarbose (a...

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Gepubliceerd in:Molecules
Hoofdauteurs: Taha, Muhammad, Alshamrani, Foziah J., Rahim, Fazal, Hayat, Shawkat, Ullah, Hayat, Zaman, Khalid, Imran, Syahrul, Khan, Khalid Mohammed, Naz, Farzana
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6864627/
https://ncbi.nlm.nih.gov/pubmed/31652777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24213819
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