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Transition of the prion protein from a structured cellular form (PrP(C)) to the infectious scrapie agent (PrP(Sc))

Prion diseases in mammals are caused by a conformational transition of the cellular prion protein from its native conformation (PrP(C)) to a pathological isoform called “prion protein scrapie” (PrP(Sc)). A molecular level of understanding of this conformational transition will be helpful in unveilin...

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Bibliografske podrobnosti
izdano v:Protein Sci
Main Authors: Baral, Pravas K., Yin, Jiang, Aguzzi, Adriano, James, Michael N. G.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley & Sons, Inc. 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863700/
https://ncbi.nlm.nih.gov/pubmed/31583788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3735
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