Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

Mu opioid receptor (MOR)-targeting analgesics are efficacious pain treatments, but notorious for their abuse potential. In preclinical animal models, coadministration of traditional kappa opioid receptor (KOR)-targeting agonists with MOR-targeting analgesics can decrease reward and potentiate analge...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Kaski, Shane W., White, Allison N., Gross, Joshua D., Trexler, Kristen R., Wix, Kim, Harland, Aubrie A., Prisinzano, Thomas E., Aubé, Jeffrey, Kinsey, Steven G., Kenakin, Terry, Siderovski, David P., Setola, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Special Section on The Opioid Crisis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863463/
https://ncbi.nlm.nih.gov/pubmed/31492823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.255661
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