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Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide
Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The Opiates produce analgesia and other adverse effects through activation of the mu opioid receptor (MOR) encoded by the Oprm1 gene. However, MOR and...
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| 出版年: | Sci Rep |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5583172/ https://ncbi.nlm.nih.gov/pubmed/28871199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11120-4 |
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