Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide

Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The Opiates produce analgesia and other adverse effects through activation of the mu opioid receptor (MOR) encoded by the Oprm1 gene. However, MOR and...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Roeckel, Laurie-Anne, Utard, Valérie, Reiss, David, Mouheiche, Jinane, Maurin, Hervé, Robé, Anne, Audouard, Emilie, Wood, John N., Goumon, Yannick, Simonin, Frédéric, Gaveriaux-Ruff, Claire
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5583172/
https://ncbi.nlm.nih.gov/pubmed/28871199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11120-4
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