Morphine Induces Hyperalgesia without Involvement of μ-Opioid Receptor or Morphine-3-glucuronide

Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to underlie this phenomenon. Here, in three separate studies, we empirically assess the role of M3G...

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Detalhes bibliográficos
Main Authors: Swartjes, Maarten, Mooren, René A G, Waxman, Amanda R, Arout, Caroline, van de Wetering, Koen, den Hartigh, Jan, Beijnen, Jos H, Kest, Benjamin, Dahan, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3521788/
https://ncbi.nlm.nih.gov/pubmed/23001479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00244
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