Preclinical Testing of Nalfurafine as an Opioid-sparing Adjuvant that Potentiates Analgesia by the Mu Opioid Receptor-targeting Agonist Morphine

Mu opioid receptor (MOR)-targeting analgesics are efficacious pain treatments, but notorious for their abuse potential. In preclinical animal models, coadministration of traditional kappa opioid receptor (KOR)-targeting agonists with MOR-targeting analgesics can decrease reward and potentiate analge...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Kaski, Shane W., White, Allison N., Gross, Joshua D., Trexler, Kristen R., Wix, Kim, Harland, Aubrie A., Prisinzano, Thomas E., Aubé, Jeffrey, Kinsey, Steven G., Kenakin, Terry, Siderovski, David P., Setola, Vincent
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2019
Matèries:
Special Section on The Opioid Crisis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863463/
https://ncbi.nlm.nih.gov/pubmed/31492823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.255661
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