Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats

A novel µ-opioid receptor antagonist, methocinnamox (MCAM), attenuates some abuse-related and toxic effects of opioids. This study further characterized the pharmacology of MCAM in separate groups of rats using procedures to examine antinociception, gastrointestinal motility, and withdrawal in morph...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Gerak, Lisa R., Minervini, Vanessa, Latham, Elizabeth, Ghodrati, Saba, Lillis, Katherine V., Wooden, Jessica, Disney, Alex, Husbands, Stephen M., France, Charles P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2019
Schlagworte:
Behavioral Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863459/
https://ncbi.nlm.nih.gov/pubmed/31439807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.260331
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