Methocinnamox Produces Long-Lasting Antagonism of the Behavioral Effects of µ-Opioid Receptor Agonists but Not Prolonged Precipitated Withdrawal in Rats

A novel µ-opioid receptor antagonist, methocinnamox (MCAM), attenuates some abuse-related and toxic effects of opioids. This study further characterized the pharmacology of MCAM in separate groups of rats using procedures to examine antinociception, gastrointestinal motility, and withdrawal in morph...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Pharmacol Exp Ther
Κύριοι συγγραφείς: Gerak, Lisa R., Minervini, Vanessa, Latham, Elizabeth, Ghodrati, Saba, Lillis, Katherine V., Wooden, Jessica, Disney, Alex, Husbands, Stephen M., France, Charles P.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The American Society for Pharmacology and Experimental Therapeutics 2019
Θέματα:
Behavioral Pharmacology
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863459/
https://ncbi.nlm.nih.gov/pubmed/31439807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.260331
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