GZ-11608, a Vesicular Monoamine Transporter-2 Inhibitor, Decreases the Neurochemical and Behavioral Effects of Methamphetamine

Despite escalating methamphetamine use and high relapse rates, pharmacotherapeutics for methamphetamine use disorders are not available. Our iterative drug discovery program had found that R-N-(1,2-dihydroxypropyl)-2,6-cis-di-(4-methoxyphenethyl)piperidine hydrochloride (GZ-793A), a selective vesicu...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Lee, Na-Ra, Zheng, Guangrong, Leggas, Markos, Janganati, Venumadhav, Nickell, Justin R., Crooks, Peter A., Bardo, Michael T., Dwoskin, Linda P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2019
Témata:
Neuropharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863457/
https://ncbi.nlm.nih.gov/pubmed/31413138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.258699
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