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Tandem domain swapping: determinants of multidomain protein misfolding

Tandem homologous domains in proteins are susceptible to misfolding through the formation of domain swaps, non-native conformations involving the exchange of equivalent structural elements between adjacent domains. Cutting-edge biophysical experiments have recently allowed the observation of tandem...

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Pubblicato in:Curr Opin Struct Biol
Autori principali: Lafita, Aleix, Tian, Pengfei, Best, Robert B, Bateman, Alex
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier Science 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863430/
https://ncbi.nlm.nih.gov/pubmed/31260947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2019.05.012
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