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Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins
A large range of debilitating medical conditions(1) are linked to protein misfolding, which may compete with productive folding particularly in proteins containing multiple domains(2). With 75% of the eukaryotic proteome consisting of multidomain proteins, how is inter-domain misfolding avoided? It...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3160465/ https://ncbi.nlm.nih.gov/pubmed/21623368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10099 |
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