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Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy

Theory, simulations and experimental results have suggested an important role of internal friction in the kinetics of protein folding. Recent experiments on spectrin domains provided the first evidence for a pronounced contribution of internal friction in proteins that fold on the millisecond timesc...

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Detalles Bibliográficos
Main Authors: Borgia, Alessandro, Wensley, Beth G., Soranno, Andrea, Nettels, Daniel, Borgia, Madeleine B., Hoffmann, Armin, Pfeil, Shawn H., Lipman, Everett A., Clarke, Jane, Schuler, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514500/
https://ncbi.nlm.nih.gov/pubmed/23149740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2204
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