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Transient misfolding dominates multidomain protein folding
Neighbouring domains of multidomain proteins with homologous tandem repeats have divergent sequences, probably as a result of evolutionary pressure to avoid misfolding and aggregation, particularly at the high cellular protein concentrations. Here we combine microfluidic-mixing single-molecule kinet...
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| Vydáno v: | Nat Commun |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Pub. Group
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4660218/ https://ncbi.nlm.nih.gov/pubmed/26572969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9861 |
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